Some contributions of philosophy to education

Of what use is philosophy to education? What do philosophical purposes, skills and attitudes bring to educational practice? What might they accomplish? My concern in what follows is not with any particular set of philosophical doctrines, nor am I inquiring after the educational implications of this or that philosophical viewpoint. Rather, my questions pertain to philosophical activity itself. The questions are thus quite general and they are certainly not new. But they take on special urgency when viewed in the perspective of current trends that are likely increasingly to affect our future circumstances of life and our operative conceptions of education

DUAL THERAPY TREATMENT OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA WITH BLINOTUMOMAB AND A STANDARD CHEMOTHERAPY REGIMEN

Leukemia is the number one cancer affecting children in the nation, with acute lymphoblastic leukemia being the most prevalent classification.1 While new and innovative treatment protocols have greatly increased the success rate of primary cancer patients, those who face relapse receive a much more dismal prognosis. Recent studies have shown that patients who relapse quite frequently have developed drug-resistant clones of the original cancer cells, leading to a need for various secondary treatment options. The drug-resistance is due to clonal mutations that take place within the cancer cell, most often because of an outside pressure or stress within the environment of the cell. In fact, studies show that in many cases the chemotherapy and radiation treatment administered to the leukemia patients provides the added pressures necessary to promote these clonal mutations, leading to treatment-resistant cells and the onset of relapsed leukemia. Various immunotherapies are becoming the front-line secondary treatment option due to their high success rates and innovative techniques. Monoclonal antibodies such as Blinatumomab or Inatuzumab are currently the primary targets of research for acute lymphoblastic leukemia secondary therapy. However, dual therapy treatments of cancers have shown increased rates of event-free survival, overall survival, and progression-free survival, as well as decreased rates of drug resistant cancer cells. Therefore, the goal of this review is to promote the application of dual treatment therapy on relapsed ALL cells for improved outcome, as well as on primary ALL cells for decreased drug resistance

Is philosophy of education a historical mistake? Connecting philosophy and education differently

In this article, I suggest that the question whether the proper place for philosophy of education is in the domain of philosophy or the domain of education cannot be resolved as long as we think of the connection between philosophy and education in terms of the idea of 'philosophy of education'. To substantiate this point, I look into the history of the idea of 'philosophy of education', both as a general idea and with regard to the way in which it became institutionalised in universities in the English-speaking world. I contrast this with the way in which the academic study of education developed in German-speaking countries in order to highlight that 'philosophy of education' is not the only way in which philosophy and education can be connected. Being aware that the connection between philosophy and education can be made differently not only provides a way out of the discussion about the proper identity and location of philosophy of education, but also hints at forms of philosophically informed scholarship that are more firmly based with the academic field of education rather than that they remain a halfway house in between philosophy and education

Bottom-up isotropization in classical-statistical lattice gauge theory

We compute nonequilibrium dynamics for classical-statistical SU(2) pure gauge theory on a lattice. We consider anisotropic initial conditions with high occupation numbers in the transverse plane on a characteristic scale ~ Q_s. This is used to investigate the very early stages of the thermalization process in the context of heavy-ion collisions. We find Weibel or "primary" instabilities with growth rates similar to those obtained from previous treatments employing anisotropic distributions of hard modes (particles) in the weak coupling limit. We observe "secondary" growth rates for higher-momentum modes reaching substantially larger values and we analyse them in terms of resummed loop diagrams beyond the hard-loop approximation. We find that a coarse grained pressure isotropizes "bottom-up" with a characteristic inverse rate of gamma^{-1} ~ 1 - 2 fm/c for coarse graining momentum scales of p < 1 GeV choosing an initial energy density for RHIC of epsilon = 30 GeV/fm^3. The nonequilibrium spatial Wilson loop is found to exhibit an area law and to become isotropic on a similar time scale.Comment: 22 pages, 12 figures. Phys. Rev. D version, appendix on insensitivity to volume and cutoff effects adde

Low-energy electronic properties of clean CaRuO3_3: elusive Landau quasiparticles

We have prepared high-quality epitaxial thin films of CaRuO$_3$ with residual resistivity ratios up to 55. Shubnikov-de Haas oscillations in the magnetoresistance and a $T^2$ temperature dependence in the electrical resistivity only below 1.5 K, whose coefficient is substantially suppressed in large magnetic fields, establish CaRuO$_3$ as a Fermi liquid (FL) with anomalously low coherence scale. Non-Fermi liquid (NFL) $T^{3/2}$ dependence is found between 2 and 25 K. The high sample quality allows access to the intrinsic electronic properties via THz spectroscopy. For frequencies below 0.6 THz, the conductivity is Drude-like and can be modeled by FL concepts, while for higher frequencies non-Drude behavior, inconsistent with FL predictions, is found. This establishes CaRuO$_3$ as a prime example of optical NFL behavior in the THz range.Comment: 12 pages, 21 figures including supplemental materia

Role of semicore states in the electronic structure of group-III nitrides: An exact exchange study

The bandstructure of the zinc-blende phase of AlN, GaN, InN is calculated employing the exact-exchange (EXX) Kohn-Sham density-functional theory and a pseudopotential plane-wave approach. The cation semicore d electrons are treated both as valence and as core states. The EXX bandgaps of AlN and GaN (obtained with the Ga 3d electrons included as core states) are in excellent agreement with previous EXX results, GW calculations and experiment. Inclusion of the semicore d electrons as valence states leads to a large reduction in the EXX bandgaps of GaN and InN. Contrary to common belief, the removal of the self-interaction, by the EXX approach, does not account for the large disagreement for the position of the semicore d electrons between the LDA results and experiment.Comment: 10 pages including 3 figures; related publications can be found at http://www.fhi-berlin.mpg.de/th/th.htm

Why is a noble metal catalytically active? The role of the O-Ag interaction in the function of silver as an oxidation catalyst

Extensive density-functional theory calculations, and taking into account temperature and pressure, affords a comprehensive picture of the behavior and interaction of oxygen and Ag(111), and provides valuable insight into the function of silver as an oxidation catalyst. The obtained phase-diagram reveals the most stable species present in a given environment and thus identifies (and excludes) possibly active oxygen species. In particular, for the conditions of ethylene epoxidation, a thin oxide-like structure is most stable, suggesting that such atomic O species are actuating the catalysis, in contrast to hitherto proposed molecular-like species.Comment: 4 pages including 3 figures, Related publications can be found at http://www.fhi-berlin.mpg.de/th/paper.htm